Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974885 | 1.00 | TP53 (0.41) | TP53USP2CYP3A4CYP2C9ALOX15 | |
| SCHEMBL6973296 | 0.90 | USP2 (0.42) | TP53USP2CYP3A4CYP2C9ALOX15 | |
| SCHEMBL6973300 | 0.90 | USP2 (0.42) | TP53USP2CYP3A4CYP2C9ALOX15 | |
| SCHEMBL6967502 | 0.86 | HTR6 (0.40) | TP53USP2CYP3A4CYP2C9ALOX15 | |
| SCHEMBL6967506 | 0.86 | HTR6 (0.40) | TP53USP2CYP3A4CYP2C9ALOX15 | |
| SCHEMBL6969331 | 0.83 | LTA4H (0.41) | KMT2AMAPTTDP1MEN1KDM4E | |
| SCHEMBL6972017 | 0.81 | PSEN1 (0.38) | TP53USP2CYP3A4CYP2C9ALOX15 | |
| SCHEMBL6980822 | 0.80 | PSEN1 (0.38) | KMT2AMAPTTDP1PSEN1MEN1 | |
| SCHEMBL7839568 | 0.79 | PSEN1 (0.42) | KMT2AMAPTTDP1PSEN1MEN1 | |
| SCHEMBL11440558 | 0.79 | PSEN1 (0.44) | KMT2AMAPTTDP1PSEN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894089-B9 | NOVEL HETEROCYCLIC COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | REDDYS LAB LTD DR (IN) | 2003-04-02 | — | — | EP | disclosed |
| EP-0894089-B1 | NOVEL HETEROCYCLIC COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | REDDYS LAB LTD DR (IN) | 2002-10-23 | — | — | EP | disclosed |