Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971766 | 0.90 | PSEN1 (0.40) | PSEN1PPARGMEN1KMT2AMAPT | |
| SCHEMBL8485403 | 0.84 | HTR1A (0.41) | PSEN1MEN1KMT2AMAPTTDP1 | |
| SCHEMBL6980261 | 0.82 | PSEN1 (0.43) | PSEN1PPARGMEN1KMT2AMAPT | |
| SCHEMBL7839568 | 0.82 | PSEN1 (0.42) | PSEN1PPARGMEN1KMT2AMAPT | |
| SCHEMBL11440561 | 0.82 | PSEN1 (0.44) | PSEN1PPARGMEN1KMT2AMAPT | |
| SCHEMBL7843126 | 0.82 | PSEN1 (0.44) | PSEN1PPARGMEN1KMT2AMAPT | |
| SCHEMBL11440558 | 0.82 | PSEN1 (0.44) | PSEN1PPARGMEN1KMT2AMAPT | |
| SCHEMBL29670864 | 0.82 | PSEN1 (0.44) | PSEN1PPARGMEN1KMT2AMAPT | |
| SCHEMBL6968237 | 0.82 | MEN1 (0.41) | PSEN1PPARGMEN1KMT2AMAPT | |
| SCHEMBL11601587 | 0.82 | PSEN1 (0.42) | PSEN1PPARGMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| US-5925656-A | CONTAINING A 2,4-DIOXOTRIAZOLIDINE RING | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-07-20 | — | — | US | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |