Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816365 | 0.91 | MAPT (0.40) | MAPTAPPALDH1A1TDP1KMT2A | |
| SCHEMBL6979007 | 0.90 | OPRM1 (0.41) | MAPTALDH1A1TDP1HPGDCTDSP1 | |
| SCHEMBL6978137 | 0.87 | OPRM1 (0.43) | MAPTAPPALDH1A1HPGDKMT2A | |
| SCHEMBL6981106 | 0.87 | APP (0.43) | MAPTAPPALDH1A1KMT2AHTT | |
| SCHEMBL6971971 | 0.84 | NPC1 (0.44) | MAPTALDH1A1KMT2ANPC1MAPK1 | |
| SCHEMBL7145811 | 0.81 | APP (0.38) | MAPTAPPALDH1A1CTDSP1KMT2A | |
| SCHEMBL6968252 | 0.78 | MEN1 (0.42) | MAPTALDH1A1TDP1HPGDKMT2A | |
| SCHEMBL6978140 | 0.78 | OPRM1 (0.49) | CTDSP1SMN1; SMN2L3MBTL1GAA | |
| SCHEMBL6983335 | 0.77 | HSD17B10 (0.38) | MAPTALDH1A1HPGDCTDSP1KMT2A | |
| SCHEMBL6970254 | 0.76 | OPRM1 (0.41) | MAPTAPPALDH1A1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |