Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831174 | 0.88 | HSD11B1 (0.36) | SMN1; SMN2ALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL6978402 | 0.86 | OPRM1 (0.41) | HSD17B10SMN1; SMN2GLAL3MBTL1CTDSP1 | |
| SCHEMBL6981485 | 0.82 | THRB (0.38) | ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL6979007 | 0.80 | OPRM1 (0.41) | SMN1; SMN2KDM4EALDH1A1TSHRMAPT | |
| SCHEMBL6978137 | 0.78 | OPRM1 (0.43) | SMN1; SMN2KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL6975131 | 0.77 | MAPT (0.41) | SMN1; SMN2KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL7145811 | 0.72 | APP (0.38) | SMN1; SMN2ALDH1A1MAPTGLALMNA | |
| SCHEMBL6976939 | 0.71 | GAA (0.44) | SMN1; SMN2KDM4EALDH1A1MAPTBLM | |
| SCHEMBL4114518 | 0.71 | MAPT (0.40) | SMN1; SMN2KDM4EALDH1A1TSHRMAPT | |
| SCHEMBL7816365 | 0.70 | MAPT (0.40) | SMN1; SMN2ALDH1A1MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |