Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978137 | 0.91 | OPRM1 (0.43) | OPRM1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6975131 | 0.90 | MAPT (0.41) | CTDSP1MEN1KMT2ALMNATDP1 | |
| SCHEMBL6979724 | 0.86 | OPRM1 (0.45) | OPRM1GLACTDSP1MEN1KMT2A | |
| SCHEMBL7145811 | 0.84 | APP (0.38) | OPRM1GLACTDSP1MEN1KMT2A | |
| SCHEMBL7816365 | 0.81 | MAPT (0.40) | OPRM1MEN1KMT2ALMNATDP1 | |
| SCHEMBL6970254 | 0.81 | OPRM1 (0.41) | OPRM1KIF11MEN1KMT2ALMNA | |
| SCHEMBL6978140 | 0.80 | OPRM1 (0.49) | OPRM1GLACTDSP1OPRD1OPRK1 | |
| SCHEMBL6983335 | 0.80 | HSD17B10 (0.38) | GLACTDSP1KMT2ALMNAALDH1A1 | |
| SCHEMBL6975804 | 0.79 | OPRM1 (0.41) | OPRM1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6968252 | 0.78 | MEN1 (0.42) | MEN1KMT2ALMNATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |