Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27490543 | 0.85 | LOXL2 (0.56) | LOXL2HDAC6IDO1TRPV1SENP7 | |
| SCHEMBL2956510 | 0.82 | LOXL2 (0.62) | LOXL2HDAC6IDO1SMN1; SMN2NPSR1 | |
| SCHEMBL584581 | 0.79 | LOXL2 (0.74) | LOXL2HDAC6IDO1TRPV1SMN1; SMN2 | |
| SCHEMBL27506992 | 0.75 | APP (0.50) | LOXL2SENP7SMN1; SMN2CASP3SENP8 | |
| SCHEMBL28201976 | 0.74 | LOXL2 (0.46) | LOXL2HDAC6 | |
| SCHEMBL27490542 | 0.74 | LOXL2 (0.58) | LOXL2HDAC6IDO1TRPV1SENP7 | |
| SCHEMBL20016669 | 0.72 | SLC5A2 (0.48) | IDO1SENP7SMN1; SMN2CASP3SENP8 | |
| SCHEMBL1998753 | 0.72 | LOXL2 (0.60) | LOXL2HDAC6IDO1TRPV1SENP7 | |
| SCHEMBL27491590 | 0.71 | HDAC6 (0.44) | LOXL2HDAC6TRPV1SMN1; SMN2NPC1 | |
| SCHEMBL201922 | 0.71 | LOXL2 (0.72) | LOXL2HDAC6IDO1TRPV1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296967-A1 | QUINOLINYL AND BENZOTHIAZOLYL PPAR-GAMMA MODULATORS | Tularik Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000633-A1 | QUINOLINYL AND BENZOTHIAZOLYL PPAR-GAMMA MODULATORS | TULARIK INC. (US) | 2002-01-03 | — | — | WO | disclosed |