Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979276 | 0.81 | TSHR (0.53) | ALDH1A1TSHRCYP19A1LMNACYP1A2 | |
| SCHEMBL3722491 | 0.78 | RIPK1 (0.45) | ALDH1A1TSHRCYP19A1LMNACYP1A2 | |
| SCHEMBL10918542 | 0.77 | TSHR (0.71) | ALDH1A1TSHRCYP19A1LMNACYP1A2 | |
| SCHEMBL6981018 | 0.75 | MAOB (0.42) | ALDH1A1CYP19A1MAPTSIGMAR1KDM4E | |
| SCHEMBL6978567 | 0.74 | ALDH1A1 (0.50) | ALDH1A1SIGMAR1MEN1KMT2AMAOB | |
| SCHEMBL6978736 | 0.74 | TSHR (0.51) | ALDH1A1TSHRCYP19A1LMNACYP1A2 | |
| SCHEMBL11286333 | 0.73 | TSHR (0.45) | ALDH1A1TSHRCYP19A1LMNACYP1A2 | |
| SCHEMBL6979279 | 0.73 | TSHR (0.57) | ALDH1A1TSHRCYP19A1LMNACYP1A2 | |
| SCHEMBL29864638 | 0.72 | TSHR (0.65) | ALDH1A1TSHRCYP19A1LMNACYP1A2 | |
| SCHEMBL5250015 | 0.72 | TSHR (0.65) | ALDH1A1TSHRCYP19A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343756-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002036562-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-05-10 | — | — | WO | disclosed |