Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10918542 | 0.88 | TSHR (0.71) | TSHRLMNACYP19A1THRACYP1A2 | |
| SCHEMBL5250015 | 0.86 | TSHR (0.65) | TSHRLMNACYP19A1THRACYP1A2 | |
| SCHEMBL29864638 | 0.86 | TSHR (0.65) | TSHRLMNACYP19A1THRACYP1A2 | |
| SCHEMBL10651848 | 0.84 | TSHR (0.62) | TSHRLMNACYP19A1THRACYP1A2 | |
| SCHEMBL6978736 | 0.81 | TSHR (0.51) | TSHRLMNACYP19A1THRACYP1A2 | |
| SCHEMBL6827685 | 0.80 | POLB (0.61) | TSHRCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL24622615 | 0.80 | ALDH1A1 (0.58) | TSHRLMNACYP19A1THRACYP1A2 | |
| SCHEMBL28293216 | 0.80 | TSHR (0.57) | TSHRLMNACYP19A1THRACYP1A2 | |
| SCHEMBL29768852 | 0.80 | ALDH1A1 (0.58) | TSHRLMNACYP19A1THRACYP1A2 | |
| SCHEMBL5964339 | 0.80 | POLB (0.67) | TSHRLMNACYP19A1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1222511-C | I-aryl-or-I-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-b ligands | WYETH CO (US) | 2005-10-12 | — | — | CN | disclosed |
| CN-1484638-A | I-aryl-or-I-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-b ligands | — | 2004-03-24 | — | — | CN | disclosed |
| EP-1343756-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002036562-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-05-10 | — | — | WO | disclosed |