⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969655 | 0.87 | FAAH (0.37) | — | |
| SCHEMBL6967680 | 0.86 | KMT2A (0.38) | — | |
| SCHEMBL6957978 | 0.82 | SIRT1 (0.41) | — | |
| SCHEMBL6965484 | 0.81 | FAAH (0.39) | — | |
| SCHEMBL6970691 | 0.78 | KDM4E (0.32) | — | |
| SCHEMBL6966047 | 0.78 | ESR1 (0.37) | — | |
| SCHEMBL6967724 | 0.77 | — | — | |
| SCHEMBL6976521 | 0.77 | GRM2 (0.41) | — | |
| SCHEMBL6972428 | 0.76 | DRD2 (0.35) | — | |
| SCHEMBL6965834 | 0.76 | ESR1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |