Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812840 | 0.92 | LMNA (0.52) | TSHRLMNAPOLBALDH1A1NPC1 | |
| SCHEMBL16345225 | 0.90 | LMNA (0.50) | TSHRLMNAPOLBALDH1A1NPC1 | |
| Barium SCHEMBL2592652 | 0.90 | LMNA (0.50) | TSHRLMNAPOLBALDH1A1NPC1 | |
| SCHEMBL3757540 | 0.90 | LMNA (0.50) | TSHRLMNAPOLBALDH1A1NPC1 | |
| SCHEMBL13455408 | 0.89 | TSHR (0.52) | TSHRLMNAPOLBALDH1A1NPC1 | |
| SCHEMBL13294286 | 0.87 | TSHR (0.56) | TSHRLMNAPOLBALDH1A1NPC1 | |
| SCHEMBL13294307 | 0.87 | TSHR (0.50) | TSHRLMNAPOLBALDH1A1NPC1 | |
| SCHEMBL1838719 | 0.87 | PDK1 (0.47) | TSHRLMNAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL20000966 | 0.87 | LMNA (0.44) | TSHRLMNAPOLBALDH1A1NPC1 | |
| SCHEMBL6931763 | 0.87 | LMNA (0.41) | TSHRLMNAPOLBALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324997-A2 | DIOXOLANE ANALOGS FOR IMPROVED INTER-CELLULAR DELIVERY | Shire Biochem Inc. (CA) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030922-A2 | DIOXOLANE ANALOGS FOR IMPROVED INTER-CELLULAR DELIVERY | SHIRE BIOCHEM INC. (CA) | 2002-04-18 | — | — | WO | disclosed |
| WO-1997021440-A1 | A SOLUTION FOR ORAL ADMINISTRATION CONTAINING ICI 182,780 | ZENECA LIMITED (GB) | 1997-06-19 | — | — | WO | disclosed |
| US-4525203-A | ((3,4,5,6-Tetrahydro-2H-pyran-2-yl)methoxy)oxabicycloalkane herbicides | SHELL OIL COMPANY (US) | 1985-06-25 | — | — | US | disclosed |