Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6490844 | 0.74 | KDM4E (0.35) | HTR7KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20884940 | 0.64 | HRH3 (0.46) | EPHX2KDM4E | |
| SCHEMBL20883622 | 0.64 | HRH3 (0.46) | EPHX2KDM4E | |
| SCHEMBL6983136 | 0.63 | HTR2A (0.36) | HTR7KDM4ESMN1; SMN2 | |
| SCHEMBL16126520 | 0.60 | ATM (0.42) | HTR7JAK2JAK1ATM | |
| SCHEMBL11469403 | 0.58 | LMNA (0.47) | SMN1; SMN2 | |
| SCHEMBL2468499 | 0.57 | AHR (0.56) | EPHX2 | |
| SCHEMBL26342804 | 0.57 | GAA (0.43) | HTR7MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9025693 | 0.56 | MAPT (0.35) | SMN1; SMN2 | |
| SCHEMBL9023764 | 0.56 | MAPT (0.35) | KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |