Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11675232 | 0.80 | MAPT (0.56) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL4883021 | 0.79 | CA12 (0.70) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL11676039 | 0.79 | MAPT (0.73) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL6985939 | 0.79 | HPGD (0.67) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL12109051 | 0.77 | CA1 (0.52) | HPGDALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11676103 | 0.76 | MAPT (0.55) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL11673814 | 0.76 | HPGD (0.53) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL4624606 | 0.76 | HPGD (0.64) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL8312186 | 0.76 | KEAP1 (0.54) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL12376738 | 0.75 | SLC1A3 (0.60) | MAPTHPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113230240-B | 1,3-diphenylprop-2-en-1-one derivative and application thereof | 广州医科大学 | 2022-12-27 | — | — | CN | disclosed |
| CN-113230240-A | 1, 3-diphenylprop-2-en-1-one derivative and application thereof | 广州医科大学 | 2021-08-10 | — | — | CN | disclosed |
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |
| EP-1131321-A2 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031074-A2 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-06-02 | — | — | WO | disclosed |