Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134028 | 0.84 | SMN1; SMN2 (0.58) | HPGDCA1CA2ALDH1A1MEN1 | |
| SCHEMBL24667482 | 0.84 | HPGD (0.72) | HPGDRECQLCA1CA2ALDH1A1 | |
| SCHEMBL27929690 | 0.82 | CA1 (0.73) | HPGDRECQLCA1CA2ALDH1A1 | |
| SCHEMBL4753529 | 0.80 | HPGD (1.00) | HPGDRECQLCA1CA2ALDH1A1 | |
| SCHEMBL22729214 | 0.80 | CA1 (0.69) | HPGDRECQLCA1CA2ALDH1A1 | |
| SCHEMBL2589383 | 0.79 | KMT2A (0.67) | HPGDRECQLCA1CA2ALDH1A1 | |
| SCHEMBL19971754 | 0.79 | HPGD (0.65) | HPGDRECQLCA1CA2NHERF1 | |
| SCHEMBL9911362 | 0.79 | RAB9A (0.60) | HPGDRECQLCA1CA2ALDH1A1 | |
| SCHEMBL6975706 | 0.79 | MAPT (0.51) | HPGDCA1CA2ALDH1A1MEN1 | |
| Hydrazine SCHEMBL28785858 | 0.78 | CA1 (0.75) | HPGDRECQLCA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |