Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975114 | 0.90 | OPRD1 (0.44) | OPRD1OPRK1OPRM1ALDH1A1 | |
| SCHEMBL6971806 | 0.90 | OPRD1 (0.42) | OPRD1OPRK1DRD4CCR3OPRM1 | |
| SCHEMBL6970257 | 0.88 | OPRD1 (0.41) | OPRD1OPRK1OPRM1ALDH1A1 | |
| SCHEMBL6980095 | 0.85 | OPRD1 (0.38) | CYP11B2OPRD1OPRK1HRH3DRD4 | |
| SCHEMBL6972934 | 0.85 | PKM (0.45) | OPRD1OPRK1DRD4CCR3OPRM1 | |
| SCHEMBL6977389 | 0.84 | OPRD1 (0.44) | OPRD1OPRK1CCR3OPRM1 | |
| SCHEMBL6981816 | 0.83 | OPRD1 (0.48) | OPRD1OPRK1CCR3OPRM1ALDH1A1 | |
| SCHEMBL6967490 | 0.83 | OPRD1 (0.41) | OPRD1OPRK1DRD4CCR3OPRM1 | |
| SCHEMBL6979779 | 0.82 | ADRA1A (0.41) | OPRD1OPRK1CCR3 | |
| SCHEMBL6970176 | 0.81 | OPRD1 (0.45) | OPRD1OPRK1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |