Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594233 | 0.88 | KDM4E (0.44) | KDM4EHSD17B10HPGDMEN1KMT2A | |
| SCHEMBL6968938 | 0.80 | PSEN1 (0.47) | HSD17B10HRH3NPC1RAB9AHPGD | |
| SCHEMBL18253939 | 0.78 | KDM4E (0.56) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL182214 | 0.76 | KDM4E (0.59) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6969464 | 0.76 | HSD17B10 (0.40) | HSD17B10HRH3NPC1RAB9AHPGD | |
| SCHEMBL18253935 | 0.76 | KDM4E (0.53) | KDM4ENPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6850513 | 0.74 | HPGD (0.57) | HSD17B10HRH3NPC1RAB9AHPGD | |
| SCHEMBL29706725 | 0.73 | HPGD (0.51) | HSD17B10HRH3NPC1RAB9AHPGD | |
| SCHEMBL8200314 | 0.72 | HRH1 (0.53) | HSD17B10HRH3NPC1RAB9AHPGD | |
| SCHEMBL18440463 | 0.71 | KDM4E (0.53) | KDM4ENPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |