Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 8/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | ESRRA | P11474 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | FURIN | P09958 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2346173 | 0.85 | MAPT (0.59) | MAPTHPGDRAB9AMAOBMAOA | |
| SCHEMBL26327986 | 0.84 | MAPT (0.68) | MAPTHPGDRAB9AMAOBMAOA | |
| SCHEMBL4744025 | 0.84 | MAPT (0.68) | MAPTHPGDRAB9AMAOBMAOA | |
| SCHEMBL5311815 | 0.81 | KDM4E (0.51) | HPGDMAOBMAOAKMT2AHTT | |
| SCHEMBL564525 | 0.79 | RAB9A (0.70) | MAPTHPGDRAB9AMAOBMAOA | |
| SCHEMBL26818700 | 0.78 | MMP13 (0.53) | MAPTHPGDRAB9AMAOBMAOA | |
| SCHEMBL12253688 | 0.77 | MAOB (0.50) | RAB9AMAOBMAOAKMT2AALDH1A1 | |
| SCHEMBL4743462 | 0.77 | MAPT (0.49) | MAPTHPGDRAB9AMAOBMAOA | |
| SCHEMBL24489414 | 0.76 | MAPT (0.66) | MAPTHPGDRAB9AMAOBESRRA | |
| SCHEMBL13692140 | 0.76 | MAPT (0.66) | MAPTHPGDRAB9AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421855-A1 | DIARYL ETHERS | Tibotec Pharmaceuticals (IE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122162-A1 | DIARYL ETHERS | TIBOTEC PHARMACEUTICALS (IE) | 2010-10-28 | — | — | WO | disclosed |