SCHEMBL6976748

SCHEMBL6976748

FC(F)(F)c1cc(Cl)c(-n2cc(C3CC3(Br)Br)c(C(F)(F)F)n2)c(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GABRA2 P47869 3/20 0.43
GABRB2 P47870 3/20 0.43
GABRB3 P28472 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6976700 0.90 GABRA2 (0.42) GABRA2GABRB2
SCHEMBL7101511 0.89 GABRA2 (0.43) GABRA2GABRB2GABRB3
SCHEMBL7095243 0.88 GABRA2 (0.43) GABRA2GABRB2GABRB3
SCHEMBL6969574 0.86 GABRA2 (0.43) GABRA2GABRB2
SCHEMBL7094294 0.86 GABRA2 (0.42) GABRA2GABRB2GABRB3
SCHEMBL7097797 0.86 GABRA2 (0.42) GABRA2GABRB2GABRB3
SCHEMBL7082653 0.84 GABRA2 (0.40) GABRA2GABRB2GABRB3
SCHEMBL6972362 0.84 GABRA2 (0.40) GABRA2GABRB2GABRB3
SCHEMBL6959168 0.84 GABRA2 (0.45) GABRA2GABRB2GABRB3
SCHEMBL6055638 0.83 GABRB3 (0.41) GABRA2GABRB2GABRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946515-B1 PARASITICIDAL PYRAZOLES PFIZER LTD (GB) 2003-03-05 EP disclosed