SCHEMBL6976776

SCHEMBL6976776

CC1=C(C)C2=C(N)C(C)(CN3CCN(C(=O)c4ccc([N+](=O)[O-])cc4)CC3)CC2=C(C)O1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
ALDH1A1 P00352 6/20 0.44
PKM P14618 2/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 5/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
MEN1 O00255 2/20 0.44
KDM4E B2RXH2 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
GALR3 O60755 1/20 0.43
HPGD P15428 2/20 0.42
ATM Q13315 1/20 0.40
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6984892 0.88 KDM4E (0.45) CA12CA1CA2CA7CA9
SCHEMBL6982088 0.82 ALDH1A1 (0.48) ALDH1A1LMNAKMT2ASMN1; SMN2MEN1
SCHEMBL6976774 0.70 CA12 (0.44) CA12CA1CA2CA7CA9
SCHEMBL2375175 0.70 KMT2A (0.74) CA12CA1CA2CA7CA9
SCHEMBL9152022 0.69 CA12 (0.77) CA12CA1CA2CA7CA9
SCHEMBL28181299 0.68 ALDH1A1 (0.60) CA12CA1CA2CA7CA9
SCHEMBL2377381 0.67 ALDH1A1 (0.65) CA12CA1CA2CA7CA9
SCHEMBL4002999 0.66 ALDH1A1 (0.75) CA12CA1CA2CA7CA9
SCHEMBL110101 0.66 ALDH1A1 (0.72) CA12CA1CA2CA7CA9
SCHEMBL12630802 0.66 CA12 (0.59) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
EP-0923575-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS Takeda Chemical Industries, Ltd. (JP) 1999-06-23 EP disclosed
WO-1998008842-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-05 WO disclosed