SCHEMBL6976774

SCHEMBL6976774

Cc1c(C)c2c(c(C)c1N)CC(C)(CN1CCN(C(=O)c3ccc([N+](=O)[O-])cc3)CC1)O2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
ALDH1A1 P00352 5/20 0.44
PKM P14618 2/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 5/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
MEN1 O00255 2/20 0.44
KDM4E B2RXH2 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
GALR3 O60755 1/20 0.43
ATM Q13315 1/20 0.40
HPGD P15428 1/20 0.40
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6984699 0.89 ALDH1A1 (0.40) ALDH1A1PKMLMNAKMT2ASMN1; SMN2
SCHEMBL6984884 0.88 KDM4E (0.45) CA12CA1CA2CA7CA9
SCHEMBL8579633 0.87 DRD3 (0.40) ALDH1A1LMNAKMT2ASMN1; SMN2MEN1
SCHEMBL6983343 0.86 DRD2 (0.46) CA12CA1CA2CA7CA9
SCHEMBL6982084 0.82 ALDH1A1 (0.48) ALDH1A1LMNAKMT2ASMN1; SMN2MEN1
SCHEMBL6978716 0.79 MEN1 (0.48) CA12CA1CA2CA7CA9
SCHEMBL6981792 0.77 POLB (0.47) CA12CA1CA2CA7CA9
SCHEMBL6977655 0.77 TSHR (0.47) ALDH1A1KMT2ASMN1; SMN2MEN1KDM4E
SCHEMBL6975992 0.76 TSHR (0.44) ALDH1A1LMNAKMT2AMEN1KDM4E
SCHEMBL6980780 0.75 CACNA2D1 (0.43) HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
EP-0923575-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS Takeda Chemical Industries, Ltd. (JP) 1999-06-23 EP disclosed
WO-1998008842-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-05 WO disclosed