Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA3 | O75311 | 1/20 | 0.38 |
| ▸ | GLRB | P48167 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30723220 | 0.82 | — | — | |
| SCHEMBL9431575 | 0.74 | GLRA3 (0.32) | GLRA3GLRB | |
| SCHEMBL9120689 | 0.71 | PTGS1 (0.35) | PTGS1PTGS2 | |
| SCHEMBL1146219 | 0.68 | TSHR (0.38) | — | |
| Hydrochloric Acid SCHEMBL2032392 | 0.65 | TSHR (0.36) | — | |
| Potassium SCHEMBL30932480 | 0.65 | TSHR (0.36) | — | |
| SCHEMBL29223372 | 0.65 | TSHR (0.36) | — | |
| Oteracil SCHEMBL7697987 | 0.64 | ALOX15 (0.32) | — | |
| SCHEMBL10110991 | 0.62 | ALDH1A1 (0.37) | — | |
| SCHEMBL25136496 | 0.61 | ALDH1A1 (0.42) | GLRA3GLRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356898-A | Antiinflammatory agents, antiallergens, antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1994-10-18 | — | — | US | claimed |
| EP-0569493-A4 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | — | 1993-11-24 | — | — | EP | claimed |
| EP-0569493-A1 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | WARNER-LAMBERT COMPANY (US) | 1993-11-18 | — | — | EP | claimed |
| WO-1992013844-A1 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | WARNER-LAMBERT COMPANY (US) | 1992-08-20 | — | — | WO | claimed |
| EP-0652874-B1 | 2-HETEROCYCLIC-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER LAMBERT CO (US) | 2003-11-05 | — | — | EP | disclosed |
| US-5432181-A | Substituted heteroaryl analogs of 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| EP-0652874-A1 | 2-HETEROCYCLIC-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1995-05-17 | — | — | EP | disclosed |
| US-5356898-A | Antiinflammatory agents, antiallergens, antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5340815-A | Inhibitors of 5-lipoxygenase and/or cyclooxygenase | WARNER-LAMBERT COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5312821-A | Antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1994-05-17 | — | — | US | disclosed |
| WO-1994003448-A1 | 2-HETEROCYCLIC-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |
| EP-0569493-A4 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | — | 1993-11-24 | — | — | EP | disclosed |
| EP-0569491-A1 | 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-11-18 | — | — | EP | disclosed |
| EP-0569493-A1 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | WARNER-LAMBERT COMPANY (US) | 1993-11-18 | — | — | EP | disclosed |
| US-5240929-A | Lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-08-31 | — | — | US | disclosed |
| US-5187175-A | 2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| WO-1992013844-A1 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | WARNER-LAMBERT COMPANY (US) | 1992-08-20 | — | — | WO | disclosed |
| WO-1992013536-A1 | 2-SUBSTITUTED-4,6-DI-TERTIARY-BUTYL-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-20 | — | — | WO | disclosed |