Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976960 | 0.77 | GLRA3 (0.38) | PTGS1PTGS2 | |
| SCHEMBL9120689 | 0.67 | PTGS1 (0.35) | PTGS1PTGS2 | |
| SCHEMBL21366422 | 0.67 | SMN1; SMN2 (0.41) | MEN1KMT2ACYP1A2SMN1; SMN2 | |
| SCHEMBL11142404 | 0.66 | MEN1 (0.40) | PTGS1ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL28806428 | 0.66 | HTT (0.47) | PTGS1ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL21366306 | 0.65 | DPP4 (0.39) | MEN1KMT2ACYP1A2SMN1; SMN2 | |
| SCHEMBL632901 | 0.65 | KDM4E (0.39) | ALDH1A1 | |
| SCHEMBL12883191 | 0.60 | CYP1A2 (0.47) | ALDH1A1KMT2ACYP1A2SMN1; SMN2 | |
| SCHEMBL15148333 | 0.60 | APLNR (0.41) | PTGS1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22092246 | 0.58 | AGBL2 (0.38) | PTGS1MEN1KMT2ASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652874-B1 | 2-HETEROCYCLIC-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER LAMBERT CO (US) | 2003-11-05 | — | — | EP | disclosed |
| EP-0652874-A1 | 2-HETEROCYCLIC-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1995-05-17 | — | — | EP | disclosed |
| US-5312821-A | Antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1994-05-17 | — | — | US | disclosed |
| WO-1994003448-A1 | 2-HETEROCYCLIC-5-HYDROXY-1,3-PYRIMIDINES USEFUL AS ANTIINFLAMMATORY AGENTS | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |
| US-5240929-A | Lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-08-31 | — | — | US | disclosed |