Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP3 | P08254 | 4/20 | 0.35 |
| ▸ | MMP8 | P22894 | 4/20 | 0.35 |
| ▸ | MMP13 | P45452 | 4/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MASP2 | O00187 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983569 | 0.91 | ADAM17 (0.48) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL6986120 | 0.89 | ADAM17 (0.48) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL6981622 | 0.87 | ADAM17 (0.68) | ADAM17CTSCHTR2AMMP1MMP2 | |
| SCHEMBL6986009 | 0.86 | ADAM17 (0.40) | ADAM17CTSCHTR2AMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL6986451 | 0.86 | ADAM17 (0.67) | ADAM17CTSCHTR2AMMP1MMP2 | |
| SCHEMBL6988077 | 0.86 | ADAM17 (0.39) | ADAM17CTSCMETAP2METAP1 | |
| Hydrochloric Acid SCHEMBL6984718 | 0.80 | ADAM17 (0.68) | ADAM17CTSCHTR2AMMP1MMP2 | |
| Hydrochloric Acid SCHEMBL6986409 | 0.80 | ADAM17 (0.68) | ADAM17CTSCHTR2AMMP1MMP2 | |
| SCHEMBL6942318 | 0.79 | ADAM17 (0.62) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL6943944 | 0.79 | ADAM17 (0.73) | ADAM17MMP1MMP2MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |