Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977503 | 0.77 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL22940781 | 0.74 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL30040550 | 0.73 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL2786895 | 0.73 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL24696520 | 0.73 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL6984262 | 0.68 | KCNH2 (0.31) | — | |
| SCHEMBL24696638 | 0.68 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL21074037 | 0.66 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL15498091 | 0.66 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1PIK3R1PIK3CATNK2 | |
| SCHEMBL6981932 | 0.66 | MBOAT4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946546-B1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PF MEDICAMENT (FR) | 2003-06-25 | — | — | EP | disclosed |
| US-6020345-A | Pyridin-2-yl-methylamine derivatives, method of preparing and application as medicine | PIERRE FABRE MEDICAMENT (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0946546-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PIERRE FABRE MEDICAMENT (FR) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998022459-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE | PIERRE FABRE MEDICAMENT (FR) | 1998-05-28 | — | — | WO | disclosed |