Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10197624 | 0.84 | TDP2 (0.49) | ALDH1A1NR3C1PGRKMT2AMEN1 | |
| SCHEMBL3382999 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TDP1NR3C1PGRKMT2A | |
| SCHEMBL9672682 | 0.79 | FFAR1 (0.36) | ALDH1A1TDP1NR3C1PGRKMT2A | |
| SCHEMBL3357234 | 0.79 | MAPT (0.43) | ALDH1A1TDP1NR3C1PGRKMT2A | |
| SCHEMBL25072493 | 0.77 | ALDH1A1 (0.44) | ALDH1A1TDP1NR3C1PGRKMT2A | |
| SCHEMBL3355386 | 0.77 | HSD17B10 (0.51) | ALDH1A1TSHRHSD17B10KDM4EPOLB | |
| SCHEMBL5799822 | 0.77 | GAA (0.44) | ALDH1A1TDP1KMT2AMEN1TSHR | |
| SCHEMBL30060716 | 0.76 | CA2 (0.46) | ALDH1A1KMT2AMEN1HSD17B10KDM4E | |
| SCHEMBL914279 | 0.76 | CA2 (0.46) | ALDH1A1KMT2AMEN1HSD17B10KDM4E | |
| SCHEMBL3358045 | 0.76 | ALDH1A1 (0.45) | ALDH1A1TDP1KMT2AMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140925-B1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | WYETH CORP (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6313114-B1 | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | disclosed |
| EP-1140925-A1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040580-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINYL-METHYL[3-(1H-INDOL-3-YL)-ALKYL]-AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |