Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818693 | 0.79 | MAPT (0.46) | MAPTLMNATP53PTGS2KDM4E | |
| SCHEMBL9948843 | 0.75 | HTR6 (0.48) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6975027 | 0.73 | HTR6 (0.45) | MAPTTP53PTGS2KDM4EALDH1A1 | |
| SCHEMBL6970174 | 0.70 | MAPT (0.46) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL13947533 | 0.70 | HTR6 (0.48) | MAPTMEN1KMT2ARAB9AHTR6 | |
| SCHEMBL6975974 | 0.70 | AKR1C3 (0.48) | MAPTLMNATP53PTGS2KDM4E | |
| SCHEMBL6968667 | 0.69 | HTR6 (0.48) | MAPTLMNAPTGS2ALDH1A1MEN1 | |
| SCHEMBL6970702 | 0.68 | HTR6 (0.47) | MAPTLMNAPTGS2ALDH1A1MEN1 | |
| SCHEMBL6961947 | 0.68 | CYP2D6 (0.48) | MAPTTP53KDM4EALDH1A1MEN1 | |
| SCHEMBL8610251 | 0.67 | PTGS2 (0.76) | MAPTLMNAPTGS2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | claimed |
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | disclosed |