SCHEMBL6977823

SCHEMBL6977823

O=c1nnc(=O)c1=NNc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.44
HTT P42858 1/20 0.44
DEPTOR Q8TB45 1/20 0.44
GFER P55789 2/20 0.39
TDP1 Q9NUW8 4/20 0.38
CYP1A1 P04798 1/20 0.38
TSHR P16473 1/20 0.38
CYP1B1 Q16678 1/20 0.38
MAPT P10636 8/20 0.37
MEN1 O00255 7/20 0.37
KMT2A Q03164 7/20 0.37
GAA P10253 4/20 0.37
HPGD P15428 1/20 0.37
ALOX12 P18054 1/20 0.37
MCL1 Q07820 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
RAB9A P51151 4/20 0.37
NPC1 O15118 2/20 0.37
LMNA P02545 2/20 0.37
NOX1 Q9Y5S8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6981052 0.80 ALDH1A1 (0.45) ALDH1A1GFERTDP1MAPTMEN1
SCHEMBL8856597 0.75 MAPT (0.62) ALDH1A1HTTDEPTORGFERTDP1
SCHEMBL19697129 0.69 ALDH1A1 (0.40) ALDH1A1HTTDEPTORGFERTDP1
SCHEMBL13879095 0.69 ALDH1A1 (0.40) ALDH1A1HTTDEPTORGFERTDP1
SCHEMBL6977827 0.67 DEPTOR (0.53) ALDH1A1HTTDEPTORGFERTDP1
SCHEMBL2868519 0.67 ALDH1A1 (0.44) ALDH1A1HTTDEPTORGFERTDP1
SCHEMBL9390551 0.65 MEN1 (0.57) ALDH1A1HTTDEPTORGFERTDP1
SCHEMBL14506042 0.65 GAA (0.47) ALDH1A1HTTDEPTORGFERTDP1
SCHEMBL901064 0.64 ALDH1A1 (0.41) ALDH1A1HTTDEPTORGFERTDP1
SCHEMBL143319 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6214813-B1 AZOPYRAZOLES KINETEK PHARMACEUTICALS, INC. (CA) 2001-04-10 US claimed
EP-1276723-A2 PYRAZOLE COMPOUNDS HAVING ANTI PROLIFERATIVE ACTIVITY Kinetek Pharmaceuticals, Inc. (CA) 2003-01-22 EP disclosed
US-6436915-B1 ANTIPROLIFERATIVE AND ANTITUMOR AGENTS AND ANGIOGENESIS INHIBITORS KINETEK PHARMACEUTICALS, INC. (CA) 2002-08-20 US disclosed
US-20020042501-A1 Pyrazole compounds DERMIRA (CANADA), INC. 2002-04-11 US disclosed
WO-2001077080-A2 PYRAZOLE COMPOUNDS HAVING ANTI PROLIFERATIVE ACTIVITY KINETEK PHARMACEUTICALS, INC. (CA) 2001-10-18 WO disclosed
US-6214813-B1 AZOPYRAZOLES KINETEK PHARMACEUTICALS, INC. (CA) 2001-04-10 US disclosed