SCHEMBL6977830

SCHEMBL6977830

O=C(N1CCNCC1)N1CCN(c2cc(Cl)ncn2)CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.40
CHKA P35790 1/20 0.40
HSP90AA1 P07900 1/20 0.40
AOC3 Q16853 1/20 0.39
CYP1A2 P05177 4/20 0.39
AKR1C3 P42330 1/20 0.39
AVPR1A P37288 1/20 0.38
OGA O60502 1/20 0.38
BPTF Q12830 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
ALDH1A1 P00352 6/20 0.37
KDM4E B2RXH2 2/20 0.37
HPGD P15428 2/20 0.37
HSD17B10 Q99714 2/20 0.37
CYP2C19 P33261 2/20 0.37
HTR3E A5X5Y0 1/20 0.37
HTR3B O95264 1/20 0.37
HTR3A P46098 1/20 0.37
HTR3D Q70Z44 1/20 0.37
HTR3C Q8WXA8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6978539 0.99 CA2 (0.39) CA2CHKAHSP90AA1AOC3CYP1A2
SCHEMBL4937062 0.83 BPTF (0.51) CYP1A2BPTFHRH4ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL4818046 0.82 BPTF (0.50) CYP1A2BPTFHRH4ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL6981399 0.81 CHRNB2 (0.48) AVPR1ASMN1; SMN2
SCHEMBL14276922 0.80 SMO (0.50) OGABPTFMEN1KMT2A
SCHEMBL6981254 0.78 GPR119 (0.53) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL6975703 0.74 LSS (0.53) ALDH1A1KDM4EMEN1KMT2AMAPT
SCHEMBL622957 0.73 GPR119 (0.56) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL4434104 0.72 CYP1A2 (0.39) CYP1A2OGABPTFHRH4ALDH1A1
SCHEMBL937322 0.71 SMN1; SMN2 (0.50) CYP1A2OGAHRH4ALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0925286-B1 SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE ASTRAZENECA AB (SE) 2003-01-02 EP disclosed
US-6093718-A AN OXIDO-SQUALENE CYCLASE INHIBITOR, ANTICHOLESTEROL AGENT FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND LOWERING CHOLESTEROL LEVELS IN BLOOD PLASMA; TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS ZENECA LIMITED (GB) 2000-07-25 US disclosed
EP-0925286-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE ZENECA LIMITED (GB) 1999-06-30 EP disclosed
WO-1998006705-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE ZENECA LIMITED (GB) 1998-02-19 WO disclosed