Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293957 | 0.82 | KDM4E (0.48) | KDM4EHSD17B10CDC25ACDC25BTDP1 | |
| SCHEMBL8796385 | 0.82 | SRD5A2 (0.55) | KDM4ECYP2C9CYP2C8POLBSRD5A2 | |
| SCHEMBL7427407 | 0.76 | KMT2A (0.55) | KDM4ETDP1L3MBTL1CYP2C9SRD5A2 | |
| SCHEMBL2436576 | 0.75 | CES2 (0.50) | KDM4EPOLBHPGDMEN1KMT2A | |
| SCHEMBL8012007 | 0.75 | POLB (0.55) | TDP1POLBHPGDMEN1KMT2A | |
| SCHEMBL766131 | 0.75 | ATM (0.76) | HSD17B10ATMTDP1L3MBTL1CYP2C9 | |
| SCHEMBL464994 | 0.75 | KDM4E (0.70) | KDM4EHSD17B10CDC25ACDC25BATM | |
| SCHEMBL10640903 | 0.75 | MEN1 (0.59) | KDM4EATMTDP1L3MBTL1CYP2C9 | |
| SCHEMBL110317 | 0.74 | SRD5A2 (0.74) | KDM4EATMTDP1L3MBTL1CYP2C9 | |
| SCHEMBL19259379 | 0.74 | TSHR (0.50) | KDM4EL3MBTL1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200434-B1 | NEW CYTOTOXIC PYRIDO 2,3,4-kl]ACRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | UNIV BARCELONA (ES) | 2003-05-14 | — | — | EP | disclosed |
| US-6559161-B1 | Method for treating a mammal affected by a malignant tumour, which comprises administering to a mammal in need of such treatment a therapeutically effective amount of a compound of formula (I), a pharmaceutically acceptable salt | UNIVERSIDAD DE BARCELONA (ES) | 2003-05-06 | — | — | US | disclosed |
| EP-1200434-A1 | NEW CYTOTOXIC PYRIDO 2,3,4-kl]ACRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | Universidad de Barcelona (ES) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009133-A1 | NEW CYTOTOXIC PYRIDO[2,3,4-kl]ACRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | UNIVERSIDAD DE BARCELONA (ES) | 2001-02-08 | — | — | WO | disclosed |