Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PLK1 | P53350 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TNF | P01375 | 4/20 | 0.58 |
| ▸ | TNFSF11 | O14788 | 3/20 | 0.55 |
| ▸ | HTR6 | P50406 | 5/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977871 | 1.00 | SMN1; SMN2 (0.64) | SMN1; SMN2LMNAPLK1MEN1KMT2A | |
| SCHEMBL15577151 | 0.81 | LMNA (0.73) | SMN1; SMN2LMNAPLK1MEN1KMT2A | |
| SCHEMBL28502871 | 0.80 | ALOX5 (0.44) | SMN1; SMN2LMNAPLK1TNFHTR6 | |
| SCHEMBL30393652 | 0.79 | LMNA (1.00) | SMN1; SMN2LMNAPLK1MEN1KMT2A | |
| SCHEMBL949716 | 0.79 | LMNA (1.00) | SMN1; SMN2LMNAPLK1MEN1KMT2A | |
| SCHEMBL948989 | 0.79 | AKR1C3 (0.83) | SMN1; SMN2LMNAPLK1MEN1KMT2A | |
| SCHEMBL2538347 | 0.78 | ABCG2 (0.57) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2538344 | 0.78 | ABCG2 (0.57) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28502706 | 0.77 | ALOX5 (0.41) | SMN1; SMN2LMNATNFSF11HTR6HDAC1 | |
| SCHEMBL28503608 | 0.77 | PTGDR2 (0.44) | LMNAHTR6HDAC1HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |
| EP-0862560-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997019065-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |