Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | PLK1 | P53350 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.66 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.66 |
| ▸ | TNF | P01375 | 3/20 | 0.62 |
| ▸ | HTR6 | P50406 | 9/20 | 0.58 |
| ▸ | TNFSF11 | O14788 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30393652 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL949348 | 0.90 | LMNA (0.82) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL948989 | 0.88 | AKR1C3 (0.83) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL946881 | 0.86 | LMNA (0.76) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL31202601 | 0.86 | LMNA (0.76) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL946441 | 0.86 | LMNA (0.76) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL8998784 | 0.85 | LMNA (0.74) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL4926276 | 0.85 | LMNA (0.74) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL15577151 | 0.85 | LMNA (0.73) | LMNASMN1; SMN2PLK1MEN1KMT2A | |
| SCHEMBL8999130 | 0.84 | PLK1 (1.00) | LMNASMN1; SMN2PLK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105198787-A | N-benzenesulfonyl-3-acetyl indole acyl hydrazone compound, preparation method and application | UNIV HENAN SCIENCE & TECH | 2015-12-30 | — | — | CN | disclosed |
| CN-105198869-A | Oxazoline derivative and preparation method and application of oxazoline derivative and prepartion method in preparing antibacterial agent of plant pathogenic fungi | UNIV HENAN SCIENCE & TECH | 2015-12-30 | — | — | CN | disclosed |
| CN-105198787-A | N-benzenesulfonyl-3-acetyl indole acyl hydrazone compound, preparation method and application | UNIV HENAN SCIENCE & TECH | 2015-12-30 | — | — | CN | disclosed |
| CN-105061287-A | N-substituted benzenesulfonyl-3-propionyl indole derivative, preparation method and application | UNIV HENAN SCIENCE & TECH | 2015-11-18 | — | — | CN | disclosed |
| CN-105052936-A | Application for N-benzenesulfonyl-3-(2-yl-ethanoyl)-6-methylindole derivatives | UNIV HENAN SCIENCE & TECH | 2015-11-18 | — | — | CN | disclosed |
| CN-102321009-A | Arylhydrazone derivate, preparation method thereof and application in preparing anti-HIV-1 medicines | UNIV NORTHWEST A&F | 2012-01-18 | — | — | CN | disclosed |
| US-7875605-B2 | 1-Benzenesulfonyl-3-(4-methylpiperazin-1-ylmethyl)-5-nitro-1 H-indole; 1-[[5-Bromo-1-(2-Bromo-4-methoxybenzenesulfonyl)-indo1-3-yl]methyl][1,4]diazepane; useful for treating psychotic and neurodegenerative disorders e.g. schizophrenia, Alzheimer's disease, Parkinson's disease and Huntington's chorea | SUVEN LIFE SCIENCES LIMITED (IN) | 2011-01-25 | — | — | US | disclosed |
| EP-1581492-B1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2008-07-16 | — | — | EP | disclosed |
| CN-1317276-C | Indolylpiperidine compound and preparation process and use thereof | SHANGHAI PHARMACEUTICAL INST C (CN) | 2007-05-23 | — | — | CN | disclosed |
| US-20060223890-A1 | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them | SUVEN LIFE SCIENCES LIMITED (IN) | 2006-10-05 | — | — | US | disclosed |
| EP-1581492-A1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | Suven Life Sciences Limited (IN) | 2005-10-05 | — | — | EP | disclosed |
| US-6906095-B2 | Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-06-14 | — | — | US | disclosed |
| WO-2004048330-A1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-06-10 | — | — | WO | disclosed |
| US-20040002527-A1 | Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH | 2004-01-01 | — | — | US | disclosed |
| CN-1345724-A | Indolylpiperidine compound and preparation process and use thereof | SHANGHAI PHARMACEUTICAL INST C (CN) | 2002-04-24 | — | — | CN | disclosed |
| US-5210193-A | Bactericide | AMERICAN CYANAMID COMPANY (US) | 1993-05-11 | — | — | US | disclosed |
| US-4940710-A | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002527-A1 | Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2A | LMNA 4212/4885SMN1; SMN2 3120/4885PLK1 2857/4885 |
| US-20060223890-A1 | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them | HTR3A, HTR3C, HTR2C | LMNA 2304/4885SMN1; SMN2 2056/4885PLK1 1465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.