Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968881 | 0.83 | LTA4H (0.40) | ALDH1A1KDM4ESLC6A2SLC6A4TAAR1 | |
| SCHEMBL3645245 | 0.81 | POLB (0.60) | ALDH1A1KDM4EGAASLC6A2SLC6A4 | |
| SCHEMBL3347781 | 0.81 | POLB (0.60) | ALDH1A1KDM4EGAASLC6A2SLC6A4 | |
| SCHEMBL10132521 | 0.79 | POLB (0.54) | ALDH1A1KDM4EGAASLC6A2SLC6A4 | |
| SCHEMBL6976719 | 0.78 | POLB (0.59) | — | |
| SCHEMBL6972577 | 0.76 | KDM4E (0.41) | ALDH1A1KDM4EGAASLC6A2SLC6A4 | |
| SCHEMBL6980008 | 0.76 | ALOX5 (0.42) | ALDH1A1KDM4EGAAEPHX1SMN1; SMN2 | |
| SCHEMBL3366280 | 0.76 | KDM4E (0.51) | ALDH1A1KDM4EGAAEPHX1TAAR1 | |
| SCHEMBL3366388 | 0.75 | KDM4E (0.54) | ALDH1A1KDM4EGAAEPHX1TAAR1 | |
| SCHEMBL6979018 | 0.75 | POLB (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |