SCHEMBL6978264

SCHEMBL6978264

Brc1[c]cccc1Cc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.42
CALM1 P0DP23 1/20 0.42
BCL2 P10415 1/20 0.41
BCL2L1 Q07817 1/20 0.41
CTRC Q99895 1/20 0.41
ALOX5 P09917 1/20 0.36
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
IDO1 P14902 1/20 0.34
TRPA1 O75762 1/20 0.34
ALDH1A1 P00352 1/20 0.34
TSHR P16473 1/20 0.34
KEAP1 Q14145 1/20 0.34
CYP3A4 P08684 1/20 0.34
ALOX15 P16050 1/20 0.34
HIF1A Q16665 1/20 0.34
HSD17B10 Q99714 1/20 0.34
DRD2 P14416 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6972720 0.83 CYP11B1 (0.36) SMN1; SMN2ALDH1A1CYP3A4HSD17B10
SCHEMBL6982912 0.79 HRH4 (0.41)
SCHEMBL721135 0.78 CALM1 (0.44) HTR2ACALM1BCL2BCL2L1ALOX5
SCHEMBL3395146 0.76 BCL2 (0.50) HTR2ACALM1BCL2BCL2L1ALOX5
SCHEMBL8204656 0.76 HTR2A (0.47) HTR2ACALM1BCL2BCL2L1ALOX5
SCHEMBL3126217 0.76 HTR2A (0.42) HTR2ACALM1BCL2BCL2L1ALOX5
SCHEMBL2410994 0.76 HTR2A (0.42) HTR2ACALM1BCL2BCL2L1ALOX5
SCHEMBL7463754 0.76 HTR2A (0.42) HTR2ACALM1BCL2BCL2L1CTRC
SCHEMBL921223 0.76 HTR2A (0.42) HTR2ACALM1BCL2BCL2L1ALOX5
SCHEMBL6978761 0.76 GPR55 (0.46) CALM1IDO1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052498-A1 3,7-DIAZABICYCLO[3.3.1]NONANE CARBOXAMIDES AS ANTITHROMBOTIC AGENTS Council of Scientific & Industrial Research (IN) 2016-08-10 EP disclosed
WO-2015044951-A1 3,7-DIAZABICYCLO[3.3.1 ]NONANE CARBOXAMIDES AS ANTITHROMBOTIC AGENTS COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2015-04-02 WO disclosed
EP-1355904-A2 HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS Wyeth (US) 2003-10-29 EP disclosed
EP-1343756-A2 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS Wyeth (US) 2003-09-17 EP disclosed
WO-2002051837-A2 HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS WYETH (US) 2002-07-04 WO disclosed
WO-2002036562-A2 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS WYETH (US) 2002-05-10 WO disclosed