Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 9/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 8/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978264 | 0.83 | HTR2A (0.42) | CYP3A4SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL6982912 | 0.81 | HRH4 (0.41) | CYP11B1CYP11B2HRH4HRH3CYP1A2 | |
| SCHEMBL28550049 | 0.73 | KMT2A (0.47) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL27306793 | 0.69 | — | — | |
| SCHEMBL455177 | 0.69 | — | — | |
| SCHEMBL16952915 | 0.69 | — | — | |
| SCHEMBL6978761 | 0.68 | GPR55 (0.46) | — | |
| SCHEMBL8182895 | 0.68 | CYP11B1 (0.39) | CYP11B1CYP11B2CYP17A1CYP19A1CYP3A4 | |
| SCHEMBL1501358 | 0.67 | ADRA2C (0.52) | CYP11B1CYP11B2CYP17A1CYP19A1SMN1; SMN2 | |
| SCHEMBL27930849 | 0.67 | TDP1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343756-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002036562-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-05-10 | — | — | WO | disclosed |