Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.53 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | IDH2 | P48735 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.46 |
| ▸ | IDH1 | O75874 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030285 | 0.96 | TDP1 (0.61) | TDP1TRIM58NUDT1ADORA1ADORA2A | |
| SCHEMBL24218050 | 0.91 | TDP1 (0.61) | TDP1TRIM58NUDT1ADORA1ADORA2A | |
| SCHEMBL6975276 | 0.87 | ADORA2A (0.60) | TDP1TRIM58NUDT1ADORA1ADORA2A | |
| SCHEMBL24303880 | 0.87 | TRIM58 (0.54) | TDP1TRIM58NUDT1ADORA1ADORA2A | |
| SCHEMBL13765582 | 0.85 | IDH1 (0.53) | TDP1TRIM58NUDT1ADORA1ADORA2A | |
| SCHEMBL19240826 | 0.85 | IDH2 (0.69) | TDP1IDH2L3MBTL1LMNAGAA | |
| SCHEMBL22435819 | 0.84 | L3MBTL1 (0.67) | TDP1TRIM58NUDT1ADORA1ADORA2A | |
| SCHEMBL24806809 | 0.83 | TDP1 (0.49) | TDP1TRIM58NUDT1ADORA1ADORA2A | |
| SCHEMBL15131484 | 0.83 | NPC1 (0.56) | TDP1NUDT1IDH1LMNAMEN1 | |
| SCHEMBL2262628 | 0.82 | LMNA (0.59) | TDP1TRIM58NUDT1ADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037886-B1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2003-05-02 | — | — | EP | claimed |
| EP-1037886-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2000-09-27 | — | — | EP | claimed |
| WO-1999031088-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-06-24 | — | — | WO | claimed |
| EP-1037886-B1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6288228-B1 | DIAMINOTRIAZINE DERIVATIVES | ABBOTT LABORATORIES | 2001-09-11 | — | — | US | disclosed |
| US-6150362-A | ADMINISTERING 1,3,5-SUBSTITUTED TRIAZINE COMPOUNDS TO THE PATIENT SUFFERING FROM ANGIOGENIC DISEASES | ABBVIE INC. | 2000-11-21 | — | — | US | disclosed |