Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788535 | 0.85 | QDPR (0.45) | EPHX2DDB1CRBN | |
| SCHEMBL3827824 | 0.84 | EPHX2 (0.38) | EPHX2IKBKETBK1PRMT5WDR77 | |
| SCHEMBL6982209 | 0.80 | EPHX2 (0.36) | EPHX2HRH3PRMT5WDR77NOTUM | |
| SCHEMBL4301270 | 0.78 | SLC18A3 (0.48) | EPHX2HRH3 | |
| SCHEMBL6211091 | 0.77 | EPHX2 (0.34) | EPHX2HRH3PRMT5WDR77 | |
| SCHEMBL4311163 | 0.76 | TLR9 (0.42) | EPHX2HRH3 | |
| Hydrochloric Acid SCHEMBL5720133 | 0.76 | HPGD (0.40) | EPHX2HRH3DDB1CRBN | |
| SCHEMBL2334055 | 0.75 | EPHX2 (0.41) | ESR2EPHX2PRMT5WDR77NOTUM | |
| SCHEMBL6213577 | 0.73 | CYP2C9 (0.43) | HRH3 | |
| SCHEMBL6212043 | 0.73 | EPHX2 (0.36) | EPHX2PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286975-A1 | BICLYCLIC CYCLOHEXYLAMINES AND THEIR USE AS NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001092239-A1 | BICICLIC CYCLOHEXYLAMINES AND THEIR USE AS NMDA RECEPTOR ANTOGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-12-06 | — | — | WO | disclosed |