Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | CDK7 | P50613 | 3/20 | 0.30 |
| ▸ | CDK13 | Q14004 | 3/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211091 | 0.86 | EPHX2 (0.34) | EPHX2HRH3PRMT5WDR77SLC6A4 | |
| SCHEMBL6215064 | 0.83 | GRM4 (0.32) | EPHX2CDK7CDK13CDK12 | |
| SCHEMBL6978487 | 0.80 | ESR2 (0.44) | EPHX2HRH3PRMT5WDR77NOTUM | |
| SCHEMBL788535 | 0.80 | QDPR (0.45) | EPHX2 | |
| SCHEMBL6213577 | 0.79 | CYP2C9 (0.43) | HRH3SLC6A4 | |
| SCHEMBL3827824 | 0.79 | EPHX2 (0.38) | EPHX2PRMT5WDR77NOTUM | |
| SCHEMBL6212043 | 0.78 | EPHX2 (0.36) | EPHX2PRMT5WDR77 | |
| SCHEMBL6217122 | 0.78 | KDM1A (0.34) | EPHX2 | |
| SCHEMBL2334055 | 0.74 | EPHX2 (0.41) | EPHX2MAT2APRMT5WDR77NOTUM | |
| SCHEMBL4301270 | 0.74 | SLC18A3 (0.48) | EPHX2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286975-A1 | BICLYCLIC CYCLOHEXYLAMINES AND THEIR USE AS NMDA RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001092239-A1 | BICICLIC CYCLOHEXYLAMINES AND THEIR USE AS NMDA RECEPTOR ANTOGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-12-06 | — | — | WO | disclosed |