Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981221 | 0.79 | POLB (0.45) | — | |
| SCHEMBL6978536 | 0.75 | HRH3 (0.39) | HRH3NPC1RAB9ASMN1; SMN2HRH1 | |
| SCHEMBL6969464 | 0.75 | HSD17B10 (0.40) | HRH3NPC1RAB9ASMN1; SMN2HRH1 | |
| SCHEMBL6850513 | 0.73 | HPGD (0.57) | HRH3NPC1RAB9ASMN1; SMN2HRH1 | |
| SCHEMBL6975226 | 0.73 | SLC18A3 (0.43) | — | |
| SCHEMBL6978104 | 0.72 | SLC18A3 (0.42) | — | |
| SCHEMBL29706725 | 0.72 | HPGD (0.51) | HRH3NPC1RAB9ASMN1; SMN2HRH1 | |
| SCHEMBL6980218 | 0.71 | CHRM2 (0.36) | CYP2D6CYP2C9 | |
| SCHEMBL8200314 | 0.71 | HRH1 (0.53) | HRH3NPC1RAB9ASMN1; SMN2HRH1 | |
| SCHEMBL6976719 | 0.70 | POLB (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |