Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975415 | 0.75 | CHRM5 (0.35) | CHRM2CHRM1CHRM3CHRM5POLB | |
| Hydrochloric Acid SCHEMBL7140228 | 0.74 | CHRM5 (0.34) | CHRM2CHRM1CHRM3CHRM5 | |
| SCHEMBL4860168 | 0.73 | POLB (0.49) | CHRM2CHRM1CHRM3CHRM5POLB | |
| SCHEMBL6976836 | 0.73 | GAA (0.40) | — | |
| SCHEMBL6980339 | 0.72 | HRH3 (0.40) | ALDH1A1 | |
| SCHEMBL6978540 | 0.71 | HRH3 (0.41) | CYP2D6CYP2C9 | |
| SCHEMBL5560190 | 0.71 | CHRM5 (0.45) | CHRM2CHRM1CHRM3CHRM5POLB | |
| SCHEMBL6981221 | 0.69 | POLB (0.45) | POLB | |
| SCHEMBL8671012 | 0.66 | FDPS (0.47) | CHRM2CHRM1CHRM3CYP2D6ALDH1A1 | |
| SCHEMBL6978953 | 0.65 | NR1H4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |