Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYBB | P04839 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984270 | 0.87 | ALDH1A1 (0.42) | MAPTHPGDMEN1ALOX15KMT2A | |
| SCHEMBL6985472 | 0.68 | MAPT (0.38) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL18876729 | 0.65 | NPC1 (0.58) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL21872073 | 0.63 | PTPN1 (0.41) | MAPTALDH1A1KDM4ERECQLLMNA | |
| SCHEMBL15142146 | 0.63 | RAB9A (0.47) | MAPTNPC1RAB9AHSD17B1KCNJ1 | |
| SCHEMBL2610325 | 0.62 | MAPT (0.58) | MAPTNPC1RAB9AHSD17B1ALOX15 | |
| SCHEMBL688076 | 0.61 | EPHX2 (0.56) | MAPTNPC1RAB9AGAAKMT2A | |
| SCHEMBL7482694 | 0.61 | NPC1 (0.53) | MAPTNPC1RAB9AHSD17B1KCNJ1 | |
| SCHEMBL27606563 | 0.61 | MAPT (0.57) | MAPTNPC1RAB9AHSD17B1HPGD | |
| SCHEMBL7285536 | 0.60 | NOTUM (0.60) | MAPTNPC1RAB9AHSD17B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |
| EP-1131321-A2 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | ELI LILLY AND COMPANY LIMITED (GB) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031074-A2 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-06-02 | — | — | WO | disclosed |