Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984197 | 0.90 | KDM4E (0.41) | KMT2AALDH1A1 | |
| SCHEMBL6975363 | 0.88 | SRD5A1 (0.41) | MAPTNPC1MAPK1KMT2AALDH1A1 | |
| SCHEMBL6984303 | 0.78 | BRD4 (0.32) | KMT2AALDH1A1 | |
| SCHEMBL8316061 | 0.75 | CRY1 (0.35) | — | |
| SCHEMBL8317987 | 0.71 | ADRA2A (0.36) | PKML3MBTL1ALDH1A1ACACB | |
| SCHEMBL6978812 | 0.68 | MAPT (0.40) | MAPTHPGDNPC1RAB9AKCNJ1 | |
| SCHEMBL18876729 | 0.63 | NPC1 (0.58) | MAPTHPGDNPC1RAB9AKCNJ1 | |
| SCHEMBL4889668 | 0.61 | MCHR1 (0.36) | MAPTHPGDRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL3230153 | 0.60 | POLB (0.46) | MAPTHPGDKMT2AALDH1A1 | |
| SCHEMBL937684 | 0.60 | MAPT (0.55) | MAPTHPGDNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |