Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 2/20 | 0.33 |
| ▸ | MMP7 | P09237 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942460 | 0.92 | ADAM17 (0.46) | ADAM17CTSCPSMB5CTSKMMP2 | |
| SCHEMBL6981638 | 0.86 | ADAM17 (0.46) | ADAM17CTSCPSMB5CTSKMMP2 | |
| SCHEMBL6987317 | 0.85 | ADAM17 (0.44) | ADAM17PSMB5CTSKMMP2MMP3 | |
| SCHEMBL6942710 | 0.84 | ADAM17 (0.46) | ADAM17CTSCMMP2MMP3MMP7 | |
| SCHEMBL6220493 | 0.83 | ADAM17 (0.48) | ADAM17CTSCHTR2AGRIK1GRIK2 | |
| SCHEMBL6984686 | 0.83 | ADAM17 (0.48) | ADAM17CTSCHTR2AGRIK1GRIK2 | |
| SCHEMBL6986484 | 0.83 | ADAM17 (0.48) | ADAM17CTSCHTR2AGRIK1GRIK2 | |
| SCHEMBL6220502 | 0.83 | ADAM17 (0.48) | ADAM17CTSCHTR2AGRIK1GRIK2 | |
| SCHEMBL6220496 | 0.83 | ADAM17 (0.48) | ADAM17CTSCHTR2AGRIK1GRIK2 | |
| SCHEMBL6220497 | 0.83 | ADAM17 (0.48) | ADAM17CTSCHTR2AGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |