Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP7 | P09237 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942460 | 0.89 | ADAM17 (0.46) | ADAM17HTR2AGRIK1GRIK2PSMB5 | |
| SCHEMBL6984068 | 0.87 | ADAM17 (0.60) | ADAM17MMP2MMP3MMP7 | |
| SCHEMBL6979640 | 0.86 | ADAM17 (0.44) | ADAM17HTR2AGRIK1GRIK2PSMB5 | |
| SCHEMBL6987317 | 0.86 | ADAM17 (0.44) | ADAM17RENPSMB5CTSKMMP2 | |
| SCHEMBL6942710 | 0.85 | ADAM17 (0.46) | ADAM17HTR2ACTSCMMP2MMP3 | |
| SCHEMBL6220493 | 0.84 | ADAM17 (0.48) | ADAM17RENHTR2AGRIK1GRIK2 | |
| SCHEMBL6220502 | 0.84 | ADAM17 (0.48) | ADAM17RENHTR2AGRIK1GRIK2 | |
| SCHEMBL6984686 | 0.84 | ADAM17 (0.48) | ADAM17RENHTR2AGRIK1GRIK2 | |
| SCHEMBL6220496 | 0.84 | ADAM17 (0.48) | ADAM17RENHTR2AGRIK1GRIK2 | |
| SCHEMBL6220497 | 0.84 | ADAM17 (0.48) | ADAM17RENHTR2AGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |