Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28450441 | 0.81 | POLB (0.42) | GBA1 | |
| SCHEMBL9852828 | 0.71 | CA2 (0.42) | GBA1 | |
| SCHEMBL23477826 | 0.70 | POLB (0.42) | GBA1DDB1CRBNHDAC8 | |
| SCHEMBL6982093 | 0.68 | HDAC8 (0.44) | GBA1DDB1CRBNHDAC8 | |
| SCHEMBL6977385 | 0.68 | MAOB (0.37) | GBA1DDB1CRBN | |
| SCHEMBL10073907 | 0.67 | CTSC (0.43) | GBA1DDB1CRBN | |
| SCHEMBL23478123 | 0.66 | POLB (0.38) | GBA1HDAC8 | |
| SCHEMBL1558534 | 0.66 | GBA1 (0.48) | GBA1 | |
| SCHEMBL6965239 | 0.66 | POLB (0.49) | GBA1 | |
| SCHEMBL7284669 | 0.66 | GBA1 (0.44) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | claimed |