Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558534 | 0.69 | GBA1 (0.48) | GBA1 | |
| SCHEMBL33373857 | 0.69 | POLB (0.42) | GBA1 | |
| Hydrochloric Acid SCHEMBL483179 | 0.67 | MAOA (0.37) | GBA1 | |
| SCHEMBL9852828 | 0.67 | CA2 (0.42) | GBA1 | |
| SCHEMBL23477826 | 0.67 | POLB (0.42) | GBA1 | |
| SCHEMBL28450441 | 0.67 | POLB (0.42) | GBA1 | |
| SCHEMBL16707824 | 0.67 | SLC6A2 (0.40) | — | |
| SCHEMBL25408856 | 0.67 | GBA1 (0.59) | GBA1 | |
| SCHEMBL7284664 | 0.67 | CALM1 (0.42) | — | |
| SCHEMBL6979673 | 0.66 | GBA1 (0.37) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254682-A | Treating hypertension, hyperaldosteronism, congestive heart failure; glaucoma | MERCK & CO., INC. (US) | 1993-10-19 | — | — | US | disclosed |
| EP-0518675-A2 | Cyclic renin inhibitors | MERCK & CO. INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0518672-A2 | Cyclic renin inhibitors | MERCK & CO. INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0432974-A1 | Cyclic renin inhibitors | MERCK & CO. INC. (US) | 1991-06-19 | — | — | EP | disclosed |
| EP-0431972-A2 | Macrocyclic lactones having renin inhibiting properties | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |