Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26670137 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AKMT2AHTR7 | |
| SCHEMBL28555839 | 0.73 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AKMT2AHTR7 | |
| SCHEMBL4775938 | 0.73 | ALDH1A1 (0.52) | RAB9AKMT2ATSHRALDH1A1TDP1 | |
| SCHEMBL4748432 | 0.72 | CYP1A2 (0.40) | KMT2ATSHRNFE2L2ALDH1A1TDP1 | |
| SCHEMBL5583370 | 0.72 | ALDH1A1 (0.52) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL7802203 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AKMT2AHTR7 | |
| SCHEMBL28233631 | 0.72 | HTR7 (0.52) | SMN1; SMN2NPC1RAB9AKMT2ATSHR | |
| SCHEMBL11558512 | 0.72 | ACP3 (0.44) | NPC1RAB9AKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL28569559 | 0.71 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AKMT2ATSHR | |
| SCHEMBL11280865 | 0.70 | HPGD (0.45) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294686-A2 | INDOLE DERIVATIVES AND THEIR USE AS 15-LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096299-A2 | INDOLE DERIVATIVES AND THEIR USE AS 15-LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-12-20 | — | — | WO | disclosed |