Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 5/20 | 0.42 |
| ▸ | BRAF | P15056 | 5/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969315 | 0.88 | MAPK14 (0.60) | MAPK14RAF1BRAF | |
| SCHEMBL6964508 | 0.87 | MAPK14 (0.51) | MAPK14SMORAF1BRAFGBA1 | |
| SCHEMBL6975392 | 0.81 | MAPK14 (0.53) | MAPK14SMORAF1BRAF | |
| SCHEMBL6965031 | 0.79 | MAPK14 (0.42) | MAPK14SMORAF1GBA1 | |
| SCHEMBL6968978 | 0.77 | MAPK14 (0.54) | MAPK14SMORAF1BRAF | |
| SCHEMBL6978401 | 0.75 | MAPK14 (0.52) | MAPK14SMORAF1BRAF | |
| SCHEMBL6972715 | 0.75 | MAPK14 (0.52) | MAPK14SMORAF1BRAF | |
| SCHEMBL6978667 | 0.75 | MAPK14 (0.55) | MAPK14SMORAF1BRAF | |
| SCHEMBL6978092 | 0.75 | MAPK14 (0.54) | MAPK14SMORAF1BRAF | |
| SCHEMBL6977536 | 0.75 | MAPK14 (0.55) | MAPK14SMORAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | claimed |