Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964508 | 0.92 | MAPK14 (0.51) | MAPK14SMORAF1GBA1 | |
| SCHEMBL6975740 | 0.87 | MAPK14 (0.53) | MAPK14RAF1HSPB1LYN | |
| SCHEMBL6968279 | 0.86 | MAPK14 (0.52) | MAPK14RAF1HSPB1LYN | |
| SCHEMBL6975168 | 0.79 | MAPK14 (0.61) | MAPK14RAF1HSPB1GBA1 | |
| SCHEMBL6975392 | 0.79 | MAPK14 (0.53) | MAPK14SMORAF1 | |
| SCHEMBL6979925 | 0.79 | MAPK14 (0.50) | MAPK14SMORAF1GBA1 | |
| SCHEMBL6978912 | 0.78 | MAPK14 (0.46) | MAPK14MAPTSMOALDH1A1GBA1 | |
| SCHEMBL6976381 | 0.74 | HPGDS (0.54) | MAPK14RAF1LYNSMN1; SMN2ABL1 | |
| SCHEMBL6970350 | 0.74 | LMNA (0.50) | MAPK14MAPTTP53RAF1MEN1 | |
| SCHEMBL6972777 | 0.73 | HPGDS (0.55) | MAPK14RAF1LYNABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | claimed |