Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
| ▸ | FAM20C | Q8IXL6 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979937 | 0.92 | IGF1R (0.62) | IGF1RKDRBRD4CDK2EGFR | |
| SCHEMBL6979973 | 0.77 | IGF1R (0.56) | IGF1RKDRBRD4CDK2EGFR | |
| SCHEMBL6645968 | 0.74 | IGF1R (1.00) | IGF1RKDRBRD4CDK2EGFR | |
| SCHEMBL1116462 | 0.74 | IGF1R (0.79) | IGF1RKDRBRD4CDK2EGFR | |
| SCHEMBL6979822 | 0.73 | SYK (0.41) | IGF1RKDRBRD4EGFRSYK | |
| SCHEMBL6976835 | 0.73 | IGF1R (0.78) | IGF1RKDRBRD4CDK2EGFR | |
| SCHEMBL6668581 | 0.72 | IGF1R (1.00) | IGF1RKDRBRD4CDK2EGFR | |
| Gw612286X SCHEMBL21067484 | 0.71 | KDR (0.72) | IGF1RKDRBRD4CDK2EGFR | |
| SCHEMBL14770902 | 0.71 | CDK4 (0.52) | KDRCDK2EGFRSYKAURKA | |
| SCHEMBL6980742 | 0.70 | FAM20C (0.78) | IGF1RKDRBRD4CDK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |