Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.34 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | CTRC | Q99895 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15534436 | 0.89 | ALDH1A1 (0.33) | PRSS1CTRCGAAHPGDMAPK1 | |
| SCHEMBL15494004 | 0.77 | OR51E2 (0.39) | OR51E2FKBP5CRBNGAACCR2 | |
| SCHEMBL532353 | 0.77 | — | — | |
| SCHEMBL6658644 | 0.77 | OR51E2 (0.39) | OR51E2FKBP5CRBNGAACCR2 | |
| SCHEMBL2526110 | 0.76 | HTT (0.41) | OR51E2FKBP5CRBNALDH1A1CCR2 | |
| SCHEMBL5014640 | 0.74 | OR51E2 (0.37) | OR51E2FKBP5CRBN | |
| SCHEMBL2482364 | 0.73 | CHRNA7 (0.38) | OR51E2FKBP5CRBNALDH1A1CCR2 | |
| SCHEMBL15163826 | 0.72 | OR51E2 (0.32) | OR51E2FKBP5CRBN | |
| SCHEMBL4937186 | 0.72 | NOS1 (0.41) | PRSS1CTRCGAAHPGDMAPK1 | |
| SCHEMBL27374922 | 0.71 | OR51E2 (0.34) | OR51E2FKBP5CRBNPRSS1CTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821674-B1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6011028-A | Cyclic amidino agents useful as nitric oxide synthase inhibitors | G.D. SEARLE & CO. (US) | 2000-01-04 | — | — | US | disclosed |
| EP-0821674-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033175-A1 | CYCLIC AMIDINO AGENTS USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-10-24 | — | — | WO | disclosed |