Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.52 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670480 | 0.85 | MAPT (0.58) | MAPTTSHRERCC1ERCC4MAPK1 | |
| SCHEMBL837012 | 0.84 | SIRT2 (0.61) | MAPTTSHRERCC1ERCC4MAPK1 | |
| SCHEMBL6528316 | 0.83 | MAPK1 (0.57) | MAPTNOTUMTSHRMAPK1NPC1 | |
| SCHEMBL25801547 | 0.81 | NPC1 (0.56) | MAPTTSHRERCC1ERCC4MAPK1 | |
| SCHEMBL18704028 | 0.79 | NOTUM (0.55) | MAPTNOTUMALDH1A1 | |
| SCHEMBL18704236 | 0.78 | TRPA1 (0.53) | MAPTNOTUM | |
| SCHEMBL21028165 | 0.78 | TSHR (0.44) | MAPTNOTUMTSHRMAPK1RAB9A | |
| SCHEMBL25216596 | 0.77 | MAPT (0.48) | MAPTTSHRERCC1ERCC4MAPK1 | |
| SCHEMBL23588158 | 0.76 | MAPT (0.50) | MAPTTSHRERCC1ERCC4MAPK1 | |
| SCHEMBL18703953 | 0.75 | NOTUM (0.55) | MAPTNOTUMTSHRMAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |